Section: 7 | Properties and Functions of Common Drugs |
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The table 'TABLE 1. Physical Properties of Common Single-Component Drugs' has one or more different columns to those in the book version.
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The recommended form of citation is:
John R. Rumble, ed., CRC Handbook of Chemistry and Physics, 102nd Edition (Internet Version 2021), CRC Press/Taylor & Francis, Boca Raton, FL.
If a specific table is cited, use the format: "Physical Constants of Organic Compounds," in CRC Handbook of Chemistry and Physics, 102nd Edition (Internet Version 2021), John R. Rumble, ed., CRC Press/Taylor & Francis, Boca Raton, FL.

PROPERTIES AND FUNCTIONS OF COMMON DRUGS

Jessica L. Burger

These tables list the names, properties, categories, and therapeutic uses of selected single-component and multicomponent drugs. The drugs have been chosen to represent a variety of categories and are widely used throughout the world. Table 1 contains the generic (and in some cases chemical) name of single-component drugs with data on their melting point, boiling point, density, and solubility in various solvents, when available. Table 2 classifies the drugs by therapeutic categories and gives additional information about their uses. Table 3 provides an index that can be used to locate an individual single-component drug by its trade name. It should be noted that not all trade names are provided as many drugs are manufactured by more than one organization. Table 4 provides similar information for multicomponent drugs and links the components to the property data given in Table 1 through the ordering number. In all tables, the ordering number (indicated as the Drug No.) is unique to a specific single-component drug as listed in Table 1. It should be noted that most drug products in the marketplace have one or more inactive ingredients. These are not included in these tables.

References

  1. The Combined Chemical Dictionary on DVD, Version 18:1, CRC Press, Boca Raton, FL, June 2014; also available on the Internet at <www.chemnetbase.com>.
  2. Milne, G. W. A., Drugs: Synonyms and Properties, Ashgate Publishing, Aldershot, Hampshire, UK, 2000.
  3. Corey, E. J., Czakó, B., and Kürti, L., Molecules and Medicine, John Wiley & Sons, Hoboken, NJ, 2007.
  4. Physicians' Desk Reference, 67th Edition, Thomson PDR, Montvale, NJ, 2013.
  5. O’Neil, M. J., ed., The Merck Index, 15th Edition, Royal Society of Chemistry, 2013.
  6. Santa Cruz Biotechnology, Inc. <http://www.scbt.com>. Accessed August 2016.
  7. Wishart, D. S. et al., Nucleic Acids Res. 34, D668, 2006. [https://doi.org/10.1093/nar/gkj067]
  8. ChemACX. Version 16.16.2; CambridgeSoft Corporation: Cambridge, MA. Accessed August 2016.
  9. PubChem Database, National Center for Biotechnology Information  <http://pubchem.ncbi.nlm.nih.gov>. Accessed August 2016.
  10. EPI - Estimation Programs Interface Suite™, v 4.11, 2017, United States Environmental Protection Agency, Washington, DC, USA, available at <https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface>.

Physical Properties of Common Single-Component Drugs

Table 1 contains physical properties of 240 common single-component drugs. The data come from a variety of sources as listed in the references. The properties, units, and special notations are given in the table below. A few drugs have no properties listed except their physical state (in some) cases. These include monoclonal antibodies (indicated by an * after the name), drugs produced as recombinant DNA (indicated by a + after the name), and vaccines.

Table 1 Column heading Definition
Drug. no.
Entry number; also used to link to information in other tables
Common name Common name of the drug: generic or chemical
tm Melting point in °C; superscript p indicates predicted value; lit. indicates literature value

tb

Boiling point in °C; superscript p indicates predicted value; all values are for 760 mmHg unless otherwise indicated; note that some of these values are high enough that decomposition will occur before boiling; nevertheless, such information can be used for correlations and separation design
ρ Density in g mL-1; all values are for 25 °C unless otherwise indicated by numerical superscript; superscript p indicates predicted value
Phys. state Indication of whether the drug is a solid or liquid
Storage Recommendations for normal storage; RT = room temperature
Solubility H2O Solubility in water in mg mL-1 unless otherwise indicated; temperature values, when available, are given in the superscript
Solubility CH3OH Solubility in methanol in mg mL-1 unless otherwise indicated; temperature values, when available, are given in the superscript
Solubility C2H5OH Solubility in ethanol in mg mL-1 unless otherwise indicated; temperature values, when available, are given in the superscript
Solubility DMSO Solubility in dimethylsulfoxide (DMSO) in mg mL-1 unless otherwise indicated; temperature values, when available, are given in the superscript
Solubility DMF Solubility in dimethyl formamide (DMF) in mg mL-1 unless otherwise indicated; temperature values, when available, are given in the superscript

TABLE 1. Physical Properties of Common Single-Component Drugs



Drug no.Common nametm/°Ctb/°Cρ/g mL-1Phys. stateStorageSolubility H2O/mg mL-1Solubility CH3OH/mg mL-1Solubility C2H5OH/mg mL-1Solubility DMSO/mg mL-1Solubility DMF/mg mL-1
Continued on next page...
1Abatacept
2Abiraterone acetate127-130506.7p~1.1pSolid-20 °C<l25sparingly2825~2~16
3Acetaminophen168-172387.83p1.2920SolidRT0.0142050100 mmol L-1100 mmol L-1freely
4Acetylsalicylic acidSolidRT8041
5Adalimumab: heavy chain*Liquid
6Adalimumab: light chain*Liquid
7Aflibercept1.081Liquid2-8 °C>100
8Albuterol sulfate153-1551.4pSolid-20 °Cfreelyfreely
9Alendronate sodium617pSolidRT
10AllopurinolSolid4 °Cfreely
11Alprazolam228-229.5Solid40 (pH 7)
12Amitriptyline hydrochloride187-189.5Solid0.0097124
13Amlodipine133-135527.2p1.2pSolidRT75.3freely252525
14Amlodipine besylate133-135527.2p1.2pSolidRT75.3freely252525
15Amoxicillin329.9p702p1.6pSolid4 °C
16Amphetamine aspartate monohydrateSolidslightly
17Amphetamine sulfateSolidslightly
18Apixaban326.5p771p1.4pSolid4 °C<125<1251825~3
19Aripiprazole134-136Solid-20 °Cfreely


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Searching for Chemicals and Properties

The CRC Handbook of Chemistry and Physics (HBCP) contains over 700 tables in over 450 documents which may be divided into several pages, all categorised into 17 major subject areas. The search on this page works by searching the content of each page individually, much like any web search. This provides a challenge if you want to search for multiple terms and those terms exist on different pages, or if you use a synonym/abbreviation that does not exist in the document.

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